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KMID : 0616619990050020323
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Journal of Soonchunhyang Medical College
1999 Volume.5 No. 2 p.323 ~ p.329
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Evaluation of the MAST Chemiluminescent Assay (MAST CLA) Allergy System
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Abstract
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Background : Multiple allergosorbent test chemiluminescent assay (MAST CLA) allergy system is a simple method for measuring total and allergen-specific IgE antibodies in human serum. Total IgE, however, was much frequently high, even if no allergen-specific IgE antibodies could be detected in serum. The aim of this study was to evaluate total IgE class of the MAST CLA and the allergen frequencies among child and adult patients respectively.
Methods : Three hundred and ninety four patients requested for MAST CLA from June 1998 through May 1999 at Soonchunhyang Kumi hospital were evaluated. Positive rates of specific IgE and the total serum IgE level of the MAST CLA allergy system for inhalent panel were compared by child and adult patients.
Results : Two hundred and sixty six adult patients and one hundred twenty nine child patients were included in this study. The overall positive rate was 37.7%; 23.3% for child patients, 44.7% for adult patients. The average 4.3 different allergens was simultaneously detected in a single positive serum. Commonly detected allergens were Dermatophagoides farinae, Dermatophagoides pteronyssinus and house dust. Serum total IgE level of allergen-specific IgE antibody positive and adult patients was significantly higher than that of negative results and child patients(p<0.000). The number of allergen-specific IgE antibody positive results was increased in serum total IgE positive results and adult patients(p<0.000). But total IgE positive rates who had allergen specific-antibody negative patients was 89.0%; 83.8% for child patients, 92.5% for adult patients.
Conclusion : These results suggest that MAST CLA allergy system is a useful screening test to detect allergen-specific IgE antibodies. But another allergen screening tests should be used for detecting allergens, when MAST CLA total IgE class is increased over class 2 with no detectable specific IgE.
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